Inhibitory effect of Murraya koenigii against Candida albicans virulence and biofilm development
2016
Muthamil, Subramanian | Karutha Pandian, Shunmugiah
In this study, anti-infective potential of the medicinal plant Murraya koenigii was assessed through in vitro assays and microscopic analysis. The methanolic leaf extract of M. koenigii significantly inhibited the major virulence factors of Candida albicans, such as biofilm formation, yeast-to-hyphal transition, cell surface hydrophobicity, hemolysin production and filamentation. Further purification and molecular characterization of the active lead is expected to give a novel anticandidal agent for the treatment of Candida infection.
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