In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H⁺
2016
Zhao, Fan | Zhang, Limin | Zhu, Anwei | Shi, Guoyue | Tian, Yang
pH plays an important role in the biochemical, ion-regulatory, or electrical machinery of nerve and glial cells, and is considered to be related to a number of degenerative diseases. Herein, we first develop a two-channel electrochemical ratiometric biosensor for local pH determination in a live rat brain, and report the accurate pH values in the different regions of live brains upon global cerebral ischemia.
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