Alkynyliodonium Salt Mediated Alkynylation of Azlactones: Fast Access to Cα-Tetrasubstituted α-Amino Acid Derivatives
2014
Finkbeiner-Zellmann, Peter | Weckenmann, Nicole M. | Nachtsheim, Boris J.
An efficient electrophilic alkynylation of azlactones (oxazol-5(4H)-ones) is developed using alkynyl(phenyl)iodonium salts as the electrophilic alkyne source. After remarkably short reaction times, the desired alkyne functionalized azlactones are obtained in 60–97% yield and can be transformed easily into a variety of quaternary α-amino acid derivatives.
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