Pharbinilic Acid, an Allogibberic Acid from Morning Glory (Pharbitis nil)
2013
Kim, Ki Hyun | Choi, Sang Un | Son, Mi Won | Choi, Sang Zin | Clardy, Jon | Lee, Kang Ro
Pharbinilic acid (1), the first naturally occurring allogibberic acid, was isolated from ethanol extracts of morning glory (Pharbitis nil) seeds. Its absolute configuration was determined by NOESY NMR and ECD experiments. Compound 1 showed weak cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cells and weakly inhibited nitric oxide production in lipopolysaccharide-activated BV-2 microglia cells.
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