Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named "vitamin B15")
1980
Herbert, Victor | Gardner, Ann | Colman, Neville
Dichloroacetate demonstrates low grade mutagenicity in the Ames Salmonella/mammalian microsome mutagenicity test. This evidence of probable carcinogenicity must be considered in any proposed use of dichloroacetate or of pangamic acid (trade-named "vitamin B15") containing dichloroacetate. It remains possible that mutagenic impurities in the materials used in this study were responsible for the activity seen in the mutagenesis assay. If such impurities were a factor, they would still be important from a public health standpoint, since they may be used in the preparation of food additives. Sodium dichloroacetate was found to be mutagenic in the test at doses of 1 to 10 micrograms/plate. Because there is a 10% coincidence of mutagenicity by this test with carcinogenicity, the possibility that dichloroacetate might induce cancer (in patients taking it) must be seriously considered.
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