Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4
2011
Zhuang, Yibin | Teng, Xiancun | Wang, Yi | Liu, Peipei | Wang, Hui | Li, Jing | Li, Guoqiang | Zhu, Weiming
Three new cyclopentapeptides, versicoloritides A–C (1–3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1–4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC₅₀ value of 67 μM.
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