A BBE-like Oxidase, AsmF, Dictates the Formation of Naphthalenic Hydroxyl Groups in Ansaseomycin Biosynthesis
2021
Liu, Shuang He | Wei, Yuan Yuan | Xing, Yin Nan | Chen, Yu | Wang, Wen | Wang, Kai Biao | Liang, Yong | Jiao, Rui Hua | Zhang, Bo | Ge, Hui Ming
Ansaseomycins are ansamycin-type natural products produced through expression of the asm gene cluster in a heterologous host. A rare berberine bridge enzyme (BBE) like oxidase, AsmF, is encoded in the asm gene cluster. Deletion of asmF led to the accumulation of a series of structurally diverse compounds, all of which lacked the 23-hydroxyl group in naphthalenic motif. Our work demonstrated that AsmF dictated the formation of the naphthalenic hydroxyl group in ansaseomycin biosynthesis.
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