Perspectives on natural product epigenetic modulators in chemical biology and medicine
2013
Cherblanc, Fanny L. | Davidson, Robert W. M. | Di Fruscia, Paolo | Srimongkolpithak, Nitipol | Fuchter, Matthew J.
Covering: up to the end of 2012 Epigenetic processes are complex regulatory transcriptional pathways that underpin fundamental physiology and are implicated in the aetiology of many diseases. Small molecule modulators of key epigenetic targets will be central in the study of these intricate networks as well as providing highly useful start points for drug discovery efforts. In this review we will give our perspective on the current status of natural product epigenetic modulators, highlighting the limitations, challenges and opportunities for currently identified molecules, as well as potential strategies for novel compound discovery moving forward.
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