Novel chaetospirolactone and orsellide F from an endophytic fungus Chaetomium sp
2018
Xu, Qin-Lan | Xiao, Yong-Sheng | Shen, Ye | Wu, Hui-Min | Zhang, Xuan | Deng, Xin-Zhao | Wang, Ting-Ting | Li, Wei | Tan, Ren-Xiang | Jiao, Rui-Hua | Ge, Hui-Ming
Chaetospirolactone (1), a novel spiro-lactone bearing a rare 1-oxaspiro [4.4] non-7-ene-2,6-dione skeleton, and orsellide F (2), together with six known compounds (3–8), were isolated from an endophytic fungus Chaetomium sp. NF00754. Their structures were determined by interpretation of spectroscopic data. The absolute configurations of 1 and 2 were established by analysis of single X-ray crystallographic data and CD spectra. Compounds 3, 4, and 6 showed moderate acetylcholinesterase inhibitory activity with IC₅₀ values of 7.34, 5.19, and 7.67 μM, respectively.
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