Selective Monoarylation of Aromatic Ketones via C–H Bond Cleavage by Trialkylphosphine Ruthenium Catalysts
2019
Suzuki, Issei | Kondo, Hikaru | Kochi, Takuya | Kakiuchi, Fumitoshi
A catalyst system consisting of RuHCl(CO)(PⁱPr₃)₂, CsF, and a styrene derivative was found to be applicable to selective monoarylation of aromatic ketones via ortho C–H bond cleavage. The reaction of 2′-methoxyacetophenone with arylboronates gave C–H arylation products without cleaving the ortho C–O bond. Acetophenone was also converted to monoarylation products with high selectivity. Cyclohexanone was found to be an effective solvent for the C–H arylation using the catalyst system.
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