Four new phenolic constituents from the rhizomes of Gastrodia elata Blume
2019
Wang, Zhi-Wei | Li, Yun | Liu, Da-Hui | Mu, Yan | Dong, Hong-Jing | Zhou, Hong-Lei | Guo, Lan-Ping | Wang, Xiao
Four new gastrodin derivatives containing a trans-cinnamoyl unit (1–4) and nine known compounds (5–13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC₅₀ values of 10.5 and 10.2 μM, respectively.
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