Evolution of MRSA During Hospital Transmission and Intercontinental Spread
2010
Harris, Simon R. | Feil, Edward J. | Holden, Matthew T.G. | Quail, Michael A. | Nickerson, Emma K. | Chantratita, Narisara | Gardete, Susana | Tavares, Ana | Day, Nick | Lindsay, Jodi A. | Edgeworth, Jonathan D. | de Lencastre, Hermínia | Parkhill, Julian | Peacock, Sharon J. | Bentley, Stephen D.
Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library