Plasma 25-hydroxyvitamin D in pregnant Asian women and their babies
1979
Heckmatt, John Z. | Peacock, Munro | Davies, Ann E.J. | McMurray, Jennifer | Isherwood, David M.
Pregnant Asiatic women have much lower blood 25-hydroxyvitamin D (25-OHD) concentration than non-Asiatic pregnant women; this state may lead to osteomalacia in the mother and then possibly rickets in the infant. Plasma 25-OHD was measured in cord blood and in fasting blood from 44 Asian mothers after delivery, and blood was sampled from the baby 48 hours after delivery; 43 non-Asiatic cord blood samples served as control. Plasma 25-OHD levels were low--81% of the mothers and 36% of the babies were in the osteomalacic range. Four Asiatic babies had craniotabes and one had neonatal tetany; only one non-Asiatic baby had craniotabes. In 44 other pregnant Asian women, 1000 units of daily supplemental vitamin D during pregnancy significantly increased plasma 25-OHD concentrations at delivery.
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