Phase-transition contrast nanocapsules triggered by low-intensity ultrasound
2014
Li, Hao | Wang, Jianhao | Wang, Ping | Zheng, Jian | Song, Fangfang | Yin, Tinghui | Zhou, Guofu | Zheng, Rongqing | Zhang, Chao
A polymeric nanocapsule encapsulated with 1,1,1,3,3-pentafluorobutane was developed, in which 2,2,3,3,4,4,4-heptafluoro-1-butyl groups were introduced to the polymer terminal for high loading of liquid fluorocarbon. In vitro experiments demonstrate that its liquid/gas-phase transition can be triggered by mild heating. This nanocapsule can be harnessed as a contrast agent for tumor imaging under diagnostic ultrasound.
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