Fluorescent vinblastine probes for live cell imaging
2016
MeimetisThese authors contributed equally to this body of work., Labros G. | Giedt, Randy J. | Mikula, Hannes | Carlson, Jonathan C. | Kohler, Rainer H. | Pirovich, David B. | Weissleder, Ralph
Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.
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