Ruthenium-Catalyzed Brook Rearrangement Involved Domino Sequence Enabled by Acylsilane–Aldehyde Corporation
2020
Lu, Xiunan | Zhang, Jian | Xu, Liangyao | Shen, Wenzhou | Yu, Feifei | Ding, Liyuan | Zhong, Guofu
A ruthenium-catalyzed [1,2]-Brook rearrangement involved domino sequence is presented to prepare highly functionalized silyloxy indenes with atomic- and step-economy. This domino reaction is triggered by acylsilane-directed C–H activation, and the aldehyde controlled the subsequent enol cyclization/Brook Rearrangement other than β–H elimination. The protocol tolerates a broad substitution pattern, and the further synthetic elaboration of silyloxy indenes allows access to a diverse range of interesting indene and indanone derivatives.
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