Photoredox-Mediated Remote C(sp³)–H Heteroarylation of N-Alkyl Sulfonamides
2019
Deng Zhiqiang, | Li, Guo-Xing | He, Gang | Chen, Gong
A Minisci-type δ-selective C(sp³)–H heteroarylation of sulfonyl-protected primary aliphatic amines with N-heteroarenes under photoredox-catalyzed conditions was developed. The reaction typically uses a slight excess of amine reactant. The use of benziodoxole acetate (BI-OAc) oxidant and hexafluoroisopropanol solvent is critical to achieve high yield. Besides methylene C–H bonds, heteroarylation reactions of δ methyl C–H bonds also worked under more forced conditions. The reactions show a broad scope for both amine and N-heteroarene substrates, offering a straightforward method for synthesis of complex δ-heteroarylalkylmines from simple precursors.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library