Synthesis and antiviralactivity of 2,3-seco-derivatives of betulonic acid
2009
Tolmacheva, I. A. | Grishko, V. V. | Boreko, E. I. | Savinova, O. V. | Pavlova, N. I.
A lupane 2,3-seco-aldehydoacid that was oxidized further to the 2,3-seco-diacid was synthesized by Beckmann fragmentation of the α-hydroxyoxime of betulonic acid. It was found that both 2,3-seco-derivatives were capable of suppresing reproduction of Herpes type 1 and flu A viruses (EC₅₀ from 1.9 to 21.3 μM).
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