Magnesium deficiency and diuretics
1982
Swales, J.D.
Diuretics, first-line drugs in hypertension therapy, are being studied for possible adverse side effects such as increased cardiovascular morbidity from subclinical potassium and magnesium deficiency, and the prolonged diuretic-induced glucose intolerance along with the increased positive effect of reduced incidence of reinfarction in patients with ischaemic heart disease. Thiazide and loop diuretics increase urinary losses of magnesium (Mg); potassium (K) retaining diuretics do not produce this effect. The findings are supported by low Mg concentrations in skeletal muscle of patients sustaining long-term diuretic treatment for congestive heart failure. Other drugs or teatment could affect Mg stores also. Mg is important as an electrolyte, is essential in many metabolic processes for hydrolysis of adenosine triphosphate and for the maintenance of homeostasis. Disruption of basic metabolic processes is unacceptable and the consequences of Mg deficiency could be fatal, therefore, further research into the use of diuretics and the Mg/K relationship must continue. (kbc)
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