2-Methylenetetrahydropyrans: Efficient Partners in the Carbonyl Ene Reaction
2013
Liang, Guohua | Sharum, Dakin T. | Lam, Troy | Totah, Nancy I.
The carbonyl ene reaction of 2-methylenetetrahydropyrans provides a rapid, high yielding route for the preparation of β-hydroxydihydropyrans under mild conditions. This process provides a new entry for the synthesis of 2-substituted tetrahydropyrans and for the direct introduction of oxygen heterocycles into molecular frameworks.
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