Voltammetric determination of verapamil and propranolol using a glassy carbon electrode modified with functionalized multiwalled carbon nanotubes within a poly (allylamine hydrochloride) film
2013
Oliveira, Geiser Gabriel | Azzi, Déborah Christine | Vicentini, Fernando Campanhã | Sartori, Elen Romão | Fatibello-Filho, Orlando
In this report, we describe the individual determination of verapamil (VPM) and propranolol (PROP) in pharmaceutical formulations using square-wave adsorptive anodic stripping voltammetry (SWAdASV), differential-pulse adsorptive anodic stripping voltammetry (DPAdASV), and a glassy carbon electrode modified with functionalized multiwalled carbon nanotubes within a poly (allylamine hydrochloride) film. The anodic peak potential for VPM and PROP at this modified electrode was 1.09V and 0.930V (versus Ag/AgCl (3.0molL⁻¹ KCl)), respectively, in a 0.25molL⁻¹ H₂SO₄ solution. Under optimized SWAdASV and DPAdASV conditions, the obtained analytical curves were linear for VPM concentrations ranging from 5.0×10⁻⁹ to 1.1×10⁻⁷molL⁻¹, and PROP concentrations ranging from 7.4×10⁻⁸ to 1.0×10⁻⁶molL⁻¹, with detection limits of 3.6×10⁻⁹ molL⁻¹ and 2.6×10⁻⁸molL⁻¹, respectively. Both of the proposed methods were successfully applied for the individual determination of VPM and PROP in several pharmaceutical formulations. The results were in a close agreement with a 95% confidence level for those obtained using official spectrophotometric methods.
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