Sensory and pulmonary irritation of inhaled n-butylamine in CF-1 and NMRI mice
1989
Vinggaard, A. M. | Nielsen, G. D. | Fries, A. S.
Sensory and pulmonary irritation of butylamine was investigated in CF-1 and NMRI mice according to the American standard test method (ASTM E981-84). The method is based on the reflexively induced reduction of the respiratory rate of mice, when exposed to chemical irritants. Sensory irritation was investigated in normal mice, yielding RD₅₀ values (concentration which reduces the respiratory rate by 50%) of 121 and 246 ppm for CF-1 and NMRI mice, respectively. The concentration-effect curves were parallel, but had significantly different elevations, indicating a lower sensitivity of NMRI mice. Pulmonary irritation was investigated in mice, inhaling through a tracheal cannula, yielding RD₅₀ values of 300 and 362 ppm for CF-1 and NMRI mice, respectively. No statistically significant difference between either the slopes or the elevations of the concentration-effect curves was found, indicating the same level of sensitivity of CF-1 and NMRI mice regarding pulmonary irritation. It can be concluded that the 2 mice stocks gave qualitatively comparable responses, but regarding sensory irritation they responded differently quantitatively. Thus for sensory irritation investigations the RD₅₀ values obtained with NMRI mice should be multiplied by 0·49 to obtain comparable values to those, expected in the recommended stock given by E981-84.
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