Silver-catalyzed synthesis of 5-aryl-3-trifluoromethyl pyrazoles
2020
Xu, Yihui | Chen, Qiaoling | Tian, Yishi | Wu, Wei | You, Yi | Weng, Zhiqiang
A silver-catalyzed synthesis of 5-aryl-3-trifluoromethyl pyrazoles from reaction of various N′-benzylidene tolylsulfonohydrazides with ethyl 4,4,4-trifluoro-3-oxobutanoate is described. The reaction proceeds via sequential nucleophilic addition, intramolecular cyclization, elimination, and [1,5]-H shift steps to afford the trifluoromethylated pyrazole products in moderate to excellent yields. The reaction is compatible with a variety of functional groups.
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