Half-inhibition Concentrations of New Cholinesterase Inhibitors
2014
Zdražilová, Pavla | Štĕpánková, Šárka | Komers, Karel | Ventura, Karel | Čegan, Alexander
The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI₅₀ values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI₅₀ values of the commercially used drugs for the Alzheimer’s disease treatment - rivastigmine and galanthamine.
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