Partial efficacy of a Brazilian coralsnake antivenom and varespladib in neutralizing distinct toxic effects induced by sublethal Micrurus dumerilii carinicauda envenoming in rats
2022
Silva-Carvalho, Rosimeire | Gaspar, Matheus Z. | Quadros, Luiz H.B. | Lobo, Luís G.G. | Giuffrida, Rogério | Santarém, Cecília L. | Silva, Elisangela O. | Gerez, Juliana R. | Silva, Nelson J. | Hyslop, Stephen | Lomonte, Bruno | Floriano, Rafael S.
In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A₂ inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations.
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