Ni-Catalyzed Redox-Neutral Ring-Opening/Radical Addition/Ring-Closing Cascade of Cycloketone Oxime Esters and Vinyl Azides
2019
Tang, Yu-Qi | Yang, Jun-Cheng | Wang, Le | Fan, Mingjin | Guo, Li-Na
A nickel-catalyzed iminyl radical-triggered C–C bond cleavage/radical addition/cyclization cascade of oxime esters and vinyl azides is described. This protocol enables rapid access to the cyanoalkylated 3,4-dihydro-2H-pyrroles and phenanthridines in good yields via adjustment of the substrate’s properties. Moreover, these reactions proceed under mild and redox-neutral conditions with a board substrate scope and excellent functional group tolerance.
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