Preparation of Triglycerol from Glycerol and Epichlorohydrin at Room Temperature: Synthesis Optimization and Toxicity Studies
2018
Milewski, Andrzej | Dydo, Piotr | Jakóbik-Kolon, Agata | Czechowicz, Dymitr | Babilas, Dorota | Burek, Małgorzata | Waśkiewicz, Sylwia | Byczek-Wyrostek, Anna | Krawczyk, Tomasz | Kasprzycka, Anna
An alternate method of synthesizing oligoglycerols from glycerol—epichlorohydrin—KOH mixtures at room temperature is proposed. This method involves using triethanolamine as a catalyst and produced a mixture of low molecular weight oligoglycerols, mainly di- and triglycerols. Second, the method was optimized for triglycerol yield, and the product obtained was found to be similar to the commercially available Triglycerol. Superior results were achieved using a combination of electrodialysis and ion-exchange as a purification step, which allowed for polyols synthesis with a total chlorine content below 120 ppm. To validate the applicability of oligoglycerol synthesized herein as a food, cosmetic, and pharmaceutical additive, preliminary toxicity studies including the cytotoxicity, comet, and micronucleus assays are discussed.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library
