Flavin-mediated photo-oxidation for the detection of mitochondrial flavins
2016
Lee, Dong-Nam | Kim, Eunjin | Lee, Jae Hong | Kim, Jong Seung | Kang, Chulhun | Hong, Jong-In
We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φf = 6.50 × 10³ M⁻¹ cm⁻¹) at long wavelengths (maximum emission wavelength, λₘₐₓ = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.
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