Chloride-Assisted Peptide Macrocyclization
2020
Vidović, Nikolina | Horvat, Gordan | Riva, Davide | Rinkovec, Tamara | Cindro, Nikola | Tomišić, Vladislav | Speranza, Giovanna
The role of the Cl– anion as a templating agent for the synthesis of cyclopeptides was assessed through the preparation of three new homocyclolysines and other six cyclic peptides by head-to-tail lactamization. Isolated yields of products obtained by chloride-templating approach were considerably higher than those gained by a cation-promoted procedure, whereby, in some cases, only the anion-assisted synthesis yielded the desired cyclopeptides.
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