Spectrum of cytomorphology of tuberculous lymphadenitis and changes during anti-tubercular treatment
2007
Sharma, M. | Agarwal, S. | Wadhwa, N. | Mishra, K. | Gadre, D.J.
To analyse the morphological changes in tuberculous lymph nodes and the clinical response during short course anti tubercular chemotherapy. Thirty-six patients with tuberculous lymphadenitis under treatment were followed up clinically and cytologically at 0, 2, 4 and 6 months. Twenty-six (72.2%) patients had palpable lymph nodes at the end of chemotherapy. Of the 14 patients with residual lymph nodes exceeding 1 cm in size, 92.8% (13) still had evidence of continuation of the disease. Acid-fast bacilli could be found in 38.8% patients at the end of 6 months. Intense lymphocytic infiltration of granulomata in the early phase of chemotherapy predicted a favourable outcome. Following completion of anti-tubercular treatment a significant percentage of patients have persistent lymphadenopathy and harbour the disease. Morphological follow up of these patients is essential as they may be at increased risk of relapse.
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