Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity
2018
Thai, Hien Bao Dieu | Levi-Acobas, Fabienne | Yum, Soo-Young | Jang, Goo | Hollenstein, Marcel | Ahn, Dae-Ro
We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.
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