Kadcoccinic Acids A–J, Triterpene Acids from Kadsura coccinea
2015
Liang, Cheng-Qin | Shi, Yi-Ming | Wang, Wei-Guang | Hu, Zheng-Xi | Li, Yan | Zheng, Yong-Tang | Li, Xiao-Nian | Du, Xue | Pu, Jian-Xin | Xiao, Wei-Lie | Zhang, Hong-Bin | Sun, Han-Dong
Eleven triterpene acids including 10 new compounds (kadcoccinic acids A–J, 1–10) were isolated from the stems of Kadsura coccinea. Except for 10, these compounds feature a rearranged lanostane skeleton with a 6/6/5/6 tetracyclic ring system, and compounds 1 and 2 are the first examples of 2,3-seco-6/6/5/6-fused tetracyclic triterpenoids. Their structures were established primarily by spectroscopic and spectrometric methods. Additionally, the absolute configuration of 3 was determined by single-crystal X-ray diffraction. Several of the compounds isolated were tested for their anti-HIV-1 and cytotoxic activities.
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