Mimicking Enzymes: Asymmetric Induction inside a Carbamate–Based Steroidal Cleft
2019
Concellón, Carmen | Martin, Judith | Gallegos, Miguel | Fanjul-Mosteirín, Noé | Costales, Aurora | Pendás, Ángel Martín | Amo, Vicente del
Cholic acid has been elaborated into a carbamate-based tripodal architecture, which is able to promote an asymmetric organic transformation inside its chiral cavity. The nature of this steroidal catalyst has been disclosed by quantum-chemical calculations. It comprises the preorganization and confinement of the reagents within the cavity of the steroid to form a supramolecular complex held together by means of cooperative H-bond contacts. This operational mode resembles that of some enzymes.
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