Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells
2018
JiangThese authors contributed equally., Yin | Zheng, Guansheng | Duan, Qinya | Yang, Liu | Zhang, Jie | Zhang, Huatang | He, Jun | Sun, Hongyan | Ho, Derek
Two fluorescent probes (Naph-1 and Naph-2), which can be prepared via a facile process, have been developed to detect hypochlorite acid (HOCl). The N,N-dimethyl thiocarbamate group quenches the fluorescence of the probes through intramolecular charge transfer (ICT). Upon reaction with HOCl in aqueous buffer, Naph-1 shows ultra-high sensitivity towards HOCl through a 4600-fold increase in fluorescence intensity, as well as a detection limit of 2.37 nM. The probes have been applied to confocal fluorescence imaging of exogenous and endogenous HOCl in living cells.
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