Modular Access to N-Substituted cis-3,5-Diaminopiperidines
2013
Blond, Aurélie | Dockerty, Paul | Alvarez, Raquel | Turcaud, Serge | Lecourt, Thomas | Micouin, Laurent
A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-substituted cis-3,5-diaminopiperidines from a readily available bicyclic hydrazine. This new synthetic route provides a simple and general access to RNA-friendly fragments with a good chemical diversity.
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