Solid Phase Synthesis of C-Terminal Boronic Acid Peptides
2016
Behnam, Mira A. M. | Sundermann, Tom R. | Klein, Christian D.
Peptides and peptidomimetics with a C-terminal boronic acid group have prolific applications in numerous fields of research, but their synthetic accessibility remains problematic. A convenient, high yield synthesis of peptide-boronic acids on a solid support is described here, using commercially available 1-glycerol polystyrene resin. The method is compatible with Fmoc chemistry and offers a versatile approach to aryl and alkyl aminoboronic acids without additional purification steps.
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