MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1′ amides
2011
Fobian, Yvette M. | Freskos, John N. | Barta, Thomas E. | Bedell, Louis J. | Heintz, Robert | Kassab, Darren J. | Kiefer, James R. | Mischke, Brent V. | Molyneaux, John M. | Mullins, Patrick | Munie, Grace E. | Becker, Daniel P.
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1′ substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.
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