Propargylamine–isothiocyanate reaction: efficient conjugation chemistry in aqueous media
2014
Viart, H. M.-F. | Larsen, T. S. | Tassone, C. | Andresen, T. L. | Clausen, M. H.
A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2–24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.
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