Colonic vitamin D metabolism: Implications for the pathogenesis of inflammatory bowel disease and colorectal cancer
2011
Cross, Heide S. | Nittke, Thomas | Kallay, Enikö
In epidemiological studies serum levels below 30nM of 25-OHD₃, the precursor of the active vitamin D metabolite 1,25-(OH)₂D₃, were consistently associated with incidence of colorectal cancer. The active vitamin D metabolite possesses antimitotic, prodifferentiating and proapoptotic capacity in vivo and in vitro. The intestinal autocrine/paracrine vitamin D system, which is the main source of local 1,25-(OH)₂D₃ plays a critical role in maintaining both mucosal immunity and normal growth of epithelial cells. It has been hypothesized that the VDR-mediated signaling antagonizing TNF-α and IL-6 receptor-activated pro-inflammatory and proliferative intracellular pathways, may prevent development of IBD and colitis-associated colorectal cancer. Conversely, any situation that impairs the efficiency of the 1,25-(OH)₂D₃/VDR signaling system at the level of the gut mucosa, e.g. vitamin D insufficiency, may increase risk for the development of IBD and colorectal cancer. Therefore, not only adequate serum levels of the precursor 25-OHD₃ are essential, but also optimal expression of the 1α-hydroxylating enzyme CYP27B1. The 1,25-(OH)₂D₃ catabolizing hydroxylase CYP24A1 is increasingly expressed during colon cancer progression, indicating that colonocytes are released from normal growth control by the steroid hormone. Securing adequate levels of calcitriol by inhibition of catabolism and support of 1α-hydroxylation by calcium, phytoestrogens and folate could be a valid approach to control, at least in part, IBD and CRC pathogenesis.
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