Molecular basis of intestinal canonical Wnt/β-catenin BAR-1 in response to simulated microgravity in Caenorhabditis elegans
2020
Zhao, Yingyue | Dong, Shuangshuang | Kong, Yan | Rui, Qi | Wang, Dayong
In nematode Caenorhabditis elegans, an intestinal signaling cascade in canonical Wnt/β-catenin signaling pathway, including β-catenin transcriptional factor BAR-1, has been identified to be involved in the control of response to simulated microgravity. However, the downstream target(s) of BAR-1 in regulating the response to simulated microgravity are still unclear. In this study, we found that BAR-1 and its direct target of Wnt effector POP-1 functioned upstream of a Meis TALE-class transcription factor UNC-62 to regulate the response to simulated microgravity. Moreover, UNC-62 regulated the response to simulated microgravity by suppressing the function of FOXO transcriptional factor DAF-16 and its target (mitochondrial Mn-SOD/SOD-3) in insulin signaling pathway. Therefore, canonical Wnt/β-catenin signaling mediates a protective intestinal response to simulated microgravity by inducing a nucleus-mitochondria communication. Our results provide an important molecular basis for intestinal Wnt/β-catenin signaling in response to simulated microgravity in organisms.
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