Methylation of C(sp3)–H/C(sp2)–H Bonds with Methanol Catalyzed by Cobalt System
2017
Liu, Zhenghui | Yang, Zhenzhen | Yu, Xiaoxiao | Zhang, Hongye | Yu, Bo | Zhao, Yanfei | Liu, Zhimin
A highly efficient Co-based catalytic system, composed of a commercially available Co salt, a tetradentate phosphine ligand P(CH₂CH₂PPh₂)₃(PP₃), and a base (denoted as [Co]/PP₃/base), is developed for the methylation of C(sp³)–H and C(sp²)-H bonds using methanol as a methylating reagent. The Co(BF₄)₂·6H₂O/PP₃/K₂CO₃ catalytic system showed high catalytic activity for the methylation of C–H bonds in aryl alkyl ketones, aryl acetonitriles, and indoles, with wide substrate scope and good functional group tolerance, and methyl-substituted products were obtained in good to excellent yields at 100 °C. This cheap, readily available, and highly efficient Co-based catalytic system may have promising applications in methylation reaction using methanol.
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