8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
2010
Ahmadiyeh, Nasim | Pomerantz, Mark M. | Grisanzio, Chiara | Herman, Paula | Jia, Li | Almendro, Vanessa | He, Housheng Hansen | Brown, Myles | Liu, X Shirley | Davis, Matthew | Caswell, Jennifer L. | Beckwith, Christine A. | Hills, Adam | MacConaill, Laura | Coetzee, Gerhard A. | Regan, Meredith M. | Freedman, Matthew L.
The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism--as tissue-specific enhancers of MYC.
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