Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts
2012
SohtomePresent address: Synthetic Organic Laboratory, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. E-mail: sohtome@riken.jp; Fax: +81 48-462-4666; Tel: +81 48-467-9374. Yoshihiro | Nagasawa, Kazuo
This review describes recent advances by our research group in the design and applications of conformationally flexible guanidine/bisthiourea organocatalysts to facilitate unique bond-forming processes, including retro-free, enantiodivergent, entropy-controlled, and cycle-specific organocatalysis. Special emphasis is placed on the key requirements to attain high selectivity and on functional switching by exploiting the structural flexibility of our organocatalysts.
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