Copper mediated stereoselective synthesis of C-glycosides from unactivated alkynes
2013
Kusunuru, Anil Kumar | Tatina, Madhubabu | Yousuf, Syed Khalid | Mukherjee, Debaraj
A highly stereoselective rapid C-glycosylation reaction has been developed between glycal and unactivated alkynes in the presence of coppertriflate and ascorbic acid at low catalyst loading and at room temperature. A wide variety of glycals and aryl acetylenes participate in the reaction smoothly. TfOH generated during the reduction of Cu(OTf)₂ by ascorbic acid may be the active catalyst for the glycosylation.
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