Cobalt(ii)-catalyzed hydroarylation of 1,3-diynes and internal alkynes with picolinamides promoted by alcohol
2020
Gao, Yuan | Zhang, Mengfan | Wang, Chaoyu | Yang, Zhen | Wong, Sin Kiong | Feng, Ruokun | Qi, Chenze
The Co(ii)-catalyzed selective C–H alkenylation of picolinamides with 1,3-diynes has been developed. This protocol can be applied to a variety of 1,3-diynes. In addition, both symmetrical and unsymmetrical internal alkynes were well tolerated, affording the corresponding alkenyl arenes. Moreover, control experiments indicated that C–H bond cleavage may be involved in the rate-determining step. Furthermore, a deuterium incorporation product was achieved when deuterated alcohol was employed as the solvent, which suggested that alcohol was essential for the final protonolysis.
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