Synthesis of β-hydroxy-α-amino acid derivatives by the cross-dehydrogenative coupling of N-arylglycine esters with α-hydroxy ketones
2021
Wang, Junjiao | Lv, Yuyu | Shang, Yongwei | Deng, Zhoubin | Zhang, Jianzhong | Ma, Xue-E | Wang, Ke-Hu | Huang, Danfeng | Su, Yingpeng | Hu, Yulai
A formal cross-dehydrogenative coupling reaction between α-hydroxy ketones and N-arylglycine derivatives for the synthesis of various β-hydroxy-α-amino acid derivatives is disclosed. The compatibility of substrate and oxidant in this reaction is achieved by controlling the dosing sequence, and the products are successfully obtained in 29–93% yields. This work provides a new method for the synthesis of β-hydroxy-α-amino acid derivatives which possesses high efficiency, convenience, and atom economy.
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