Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

Andersson, M.; Bergendorff, O.; Nielsen, M.; Sterner, O.; Witt, R.; Ai, J.; Lu, A.; Wang, A.M.

Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

1995

S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.

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AGROVOC Keywords

binding sites drugs glutamate glutamates glutathione inhibition metabolism neurotoxins pharmacology plant extracts receptors

Bibliographic information

Published in

Phytochemistry

Volume 38 Issue 4 Pagination 835 - 836 ISSN 0031-9422

Other Subjects

Kainic acid; Chinese herbal; Antagonists & inhibitors; Gastrodia elata; Derivatives

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

1995

AGROVOC Keywords

Bibliographic information