Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: A case report and review of the literature
2016
Goldman, Chloe | Akiyama, Matthew J. | Torres, Julian | Louie, Eddie | Meehan, Shane A.
Scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. It poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. We present an immunocompromised patient with a cutaneous S. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. Adding echinocandins and GM-CSF provided partial recovery, indicating a potential synergistic role of dual-antifungal and immunotherapeutic agents.
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