Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents
2011
Lee, Suk Ho | Song, Kwang-Seop | Kim, Jong Yup | Kang, Misuk | Lee, Jun Sung | Cho, Seung-Hwan | Park, Hyun-Ju | Kim, Jeongmin | Lee, Jinhwa
Novel thiophene C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different types of thiophene derivatives were readily prepared. Among the compounds tested, ethylphenyl at the distal ring 71p showed the best in vitro inhibitory activity in this series to date (IC₅₀=4.47nM) against SGLT2.
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