Activities of overt and latent diacylglycerol acyltransferases (DGATs I and II) in liver microsomes of ob/ob mice
2002
Waterman, I.J. | Zammit, V.A.
The effect of the ob/ob mutation on microsomal overt and latent acyl CoA:diacylglycerol acyl transferase activities (DGATs I and II) in liver microsomes of mice was investigated. Overt and latent hepatic DGAT activities for 16-week-old lean Ob/? mice were 0.42±0.14 and 1.57±0.04 µmol/mg/min, respectively. For ob/ob mice DGAT I and II activities were 1.17±0.28 and 3.09±0.78 µmol/mg/min, respectively. The hepatic triacylglycerol (TAG) concentration of 16-week-old mice was increased three-fold in ob/ob mice relative to those in lean controls. The data suggest that the increased rate of hepatic TAG secretion and intracellular accumulation in ob/ob mice is accompanied by parallel increases in the activities of both DGATs.
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